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Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

NCT04488757 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-05-22

No results posted yet for this study

Summary

Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.

Conditions

  • Chronic Widespread Pain
  • Stress, Psychological
  • Stress, Physiological

Interventions

DIAGNOSTIC_TEST

functional Magnetic Resonance Imaging (fMRI)

Participants will undergo a one hour fMRI scan with pain-induction using heat-based QST protocol.

OTHER

Allostatic Load Composite

All participants will be asked to provide saliva samples to measure cortisol response over time and dehydroepiandrosterone (DHEA) in addition to physiological measurements such as blood pressure/pulse, height/weight, and waist-hip ratio. Measurements will be taken at baseline and 4-month follow-up.

Sponsors & Collaborators

Principal Investigators

  • Sarah Nelson · Boston Children's Hospital/Harvard Medical School

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
11 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-11-04
Primary Completion
2026-03-31
Completion
2026-08-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04488757 on ClinicalTrials.gov