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Blood-based Biomarkers for the Prognosis of Sports Related Concussion

NCT04485494 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2023-06-02

No results posted yet for this study

Summary

The diagnosis of sports related concussion still relies heavily on a subjective assessment. In this study the investigators want to assess the prognostic value of blood-based biomarkers with recovery from concussive episodes over specific time points post-injury. Our research aims to (1) assess that the World Rugby's head injury assessment (HIA) can identify that a concussion has taken place by measuring specific biomarkers in the blood and (2) to track these biomarkers over time post-injury as a means to assess player health.

Conditions

Interventions

DIAGNOSTIC_TEST

Biochemical Analysis of Blood Biomarkers

Using established biochemical techniques, the bloods will be probed for specific biomarkers s100B, UCH-L1, GFAP, and BDNF. The techniques include individual ELISA kits for each biomarker mentioned and Luminex multiplate assay which will probe for all biomarkers in one plate. Ultimately, these techniques will be able to measure the level of these biomarkers in the blood relative to the participants baseline reading.

Sponsors & Collaborators

  • University of Limerick

    lead OTHER

Principal Investigators

  • Jamie Kearns, MD · Munster Rugby

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2023-05-01
Completion
2023-05-01

Countries

  • Ireland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04485494 on ClinicalTrials.gov