Chasing Biomarkers in Post-concussion Syndrome

Summary

The goal of this study was to investigate the biomarkers, neurofilament light chain, inflammatory markers, calcitonin-gene-related peptide, and metabolites from the kynurenine pathway in patients with severe post-concussive symptoms. The main question it aimed to answer was:

* Are the biomarker concentrations significantly changed in patients with severe post-concussive symptoms compared to healthy individuals?
* Do the biomarker concentrations change at follow-up?

Participants were recruited from a recently published randomized controlled trial (Clinicaltrials.gov no. NCT02337101 / PMID: 31891145 ). The biomarker concentrations were compared to a healthy control group recruited from the Blood Bank at Aarhus University Hospital in 2022.

Conditions

• Post Concussive Symptoms

Interventions

BEHAVIORAL

Early intervention programme

For more information, please go to the original registration of the RCT-study (NCT02337101) or the published article (PMID: 31891145).

BEHAVIORAL

Enhanced usual care

For more information, please go to the original registration of the RCT-study (NCT02337101) or the published article (PMID: 31891145).

Sponsors & Collaborators

• Sygekassernes Helsefond

  collaborator OTHER

• Fonden til Lægevidenskabens Fremme

  collaborator OTHER

• Direktør Emil C. Hertz og Hustru Inger Hertz Fond

  collaborator UNKNOWN

• Helga Og Peter Kornings Fond

  collaborator UNKNOWN

• Region MidtJylland Denmark

  collaborator OTHER

• University of Aarhus

  lead OTHER

Principal Investigators

• Peter Preben Eggertsen, MD · Hammel Neurorehabilitation Centre and University Research Clinic and Research Unit for Molecular Medicine (Aarhus University)

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-03-31

Primary Completion

2023-07-31

Completion

2023-07-31