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Maternal-fetal Immune Responses to Fetal Surgery

NCT04484441 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2026-02-10

No results posted yet for this study

Summary

Performing surgery in utero on fetuses with certain birth defects has led to significant improvements in outcomes after birth; however, many of these infants are born preterm which can decrease the effectiveness of these procedures. The investigators aim to understand the effects of surgery on the maternal and fetal immune system and whether immune activation may be causing some of these infants to be born prematurely.

Conditions

  • Spina Bifida
  • Congenital Diaphragmatic Hernia
  • Lower Urinary Tract Obstructive Syndrome
  • Myelomeningocele

Interventions

OTHER

Blood and placenta specimen collection.

Collection of maternal and paternal blood. Collection of infant cord blood and placenta.

Sponsors & Collaborators

Principal Investigators

  • Mauro Schenone, MD · Mayo Clinic

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-24
Primary Completion
2024-12-31
Completion
2025-12-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04484441 on ClinicalTrials.gov