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The Effect of Antenatal Corticosteroids on the Fetal Thymus - a Possible Role in Fetal Immune Programming

NCT03057717 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 86

Last updated 2023-12-12

No results posted yet for this study

Summary

Administration of corticosteroids is standard practice for pregnant patients at risk of preterm labour to reduce the risk of neonatal respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and neonatal mortality. However, there is an unknown effect of antenatal steroids on both fetal and neonatal immune function. The purpose of this study is to demonstrate the effect of antenatal steroids on the size of the fetal thymus gland.

Conditions

  • Preterm Labor
  • Fetal Glucocorticoid Exposure

Interventions

OTHER

2D ultrasound assessment

2D ultrasound assessment of fetal thymus size with measurements of the maximum transverse diameter and thymus perimeter

Sponsors & Collaborators

  • Unity Health Toronto

    lead OTHER

Principal Investigators

  • Howard Berger, MD · Unity Health Toronto

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-08-20
Primary Completion
2016-09-01
Completion
2016-09-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03057717 on ClinicalTrials.gov