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Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

NCT04477330 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-05-11

No results posted yet for this study

Summary

Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mechanisms that are associated with response to the intervention.

Conditions

Interventions

OTHER

Transcranial direct current stimulation (tDCS)

1 mA tDCS

OTHER

Ankle motor training

Visuomotor target tracking task

BEHAVIORAL

High intensity interval speed based treadmill training (HIISTT)

Each treadmill session to include warm-up, high intensity speed-based intervals interleaved with active recovery, and cool down.

Sponsors & Collaborators

  • University of Maryland, College Park

    collaborator OTHER

  • Northwestern University

    collaborator OTHER

  • University of Illinois at Chicago

    lead OTHER

Principal Investigators

  • Sangeetha Madhavan · University of Illinois at Chicago

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2026-12-31
Completion
2027-08-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04477330 on ClinicalTrials.gov