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Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke

NCT05919043 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2025-07-02

No results posted yet for this study

Summary

The goal of this clinical trial is to to determine the effect of movement-based priming using the upper limbs on lower limb neuroplasticity and behaviors in chronic stroke.

The main questions we aim to answer are:

1. What are the acute effect of UL-priming on lower limb neuroplasticity and motor behaviors in persons with stroke compared to other priming modalities?
2. What are the time effects of UL-priming on neuroplasticity and motor behavior in individuals with stroke?

In this cross over study, participants will be involved in three priming sessions involving

\- UL-priming using rhythmic, symmetric, bilateral priming involving the movement of at least one major joint in the upper limbs.

AND

\- Sham priming using auditory stimulation (1 Hz metronome).

AND

\- Lower-limb movement-based priming using rhythmic, symmetric, dorsiflexion and plantarflexion movements.

Researchers will compare outcome measures between the different priming sessions.

Conditions

Interventions

OTHER

Upper limb-based movement priming (UL-priming)

Repetitive upper limb movements administered to the beat of a metronome.

OTHER

Lower limb-based movement priming (LL-priming)

Repetitive lower limb movements administered to the beat of a metronome.

OTHER

Sham priming

Auditory stimulation.

Sponsors & Collaborators

  • University of Illinois at Chicago

    lead OTHER

Principal Investigators

  • Sangeetha Madhavan, PT, PhD · University of Illinois at Chicago

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2025-06-25
Completion
2025-06-25

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05919043 on ClinicalTrials.gov