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Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

NCT06258551 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2024-02-14

No results posted yet for this study

Summary

The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or decrease the risk of acquiring an infection or becoming colonized by pathogenic bacteria. Participants will have the following samples collected during enrollment: stool samples (maximum 2x/week), blood draws (1x/week), oral swab (1x/week).

Conditions

  • Antimicrobial Drug Resistance
  • Antibiotic Resistant Infection
  • Clostridium Difficile
  • Carbapenem-Resistant Enterobacteriaceae Infection
  • Extended Spectrum Beta-Lactamase Producing Bacteria Infection
  • Vancomycin Resistant Enterococci Infection
  • Carbapenem Resistant Bacterial Infection
  • Vancomycin-Resistant Enterococcal Infection

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • M.D. Anderson Cancer Center

    collaborator OTHER

  • Baylor College of Medicine

    collaborator OTHER

  • University of Houston

    collaborator OTHER

  • William Marsh Rice University

    collaborator OTHER

  • The University of Texas Health Science Center, Houston

    collaborator OTHER

  • The Methodist Hospital Research Institute

    lead OTHER

Principal Investigators

  • Cesar A Arias, MD, PhD, Msc · The Methodist Hospital Research Institute

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-08
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06258551 on ClinicalTrials.gov