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End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)

NCT04399278 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-08-25

No results posted yet for this study

Summary

The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.

Conditions

  • Hemodynamic Instability
  • General Anesthesia
  • Surgery
  • Protective Mechanical Ventilation

Interventions

DIAGNOSTIC_TEST

Diagnostic Test: end-expiratory occlusion (EEO) test

A set of respiratory and hemodynamic measurements (including cardiac output) will be recorded at each stage: * T0: baseline. * T1: At the end of the first EEO (15 sec or 30 sec) * T2: 1 minute after completion of the first EEO. Return to baseline. * T3: At the end of the second EEO (15 sec or 30 sec) * T4: 1 minute after completion of the second EEO. Return to baseline. * T5: Before the fluid challenge test (4 ml/kg of 0.9% saline over 5 min) * T6: 1 minute after the end of the fluid challenge A first set of measurements will be performed after intubation (before the surgical incision) and will be repeated, if necessary, in case of further decrease in stroke volume during surgery or in case of any clinical indication of volume expansion (i.e., arterial persistent hypotension, major hemorrhage, etc.).

Sponsors & Collaborators

  • University Hospital, Clermont-Ferrand

    lead OTHER

Principal Investigators

  • Emmanuel Futier, PhD · University Hospital, Clermont-Ferrand

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-03
Primary Completion
2021-03-24
Completion
2021-03-24

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04399278 on ClinicalTrials.gov