The Prevalence of Small Airways Dysfunction In COPD Patients and The Impact on COPD Control

Summary

Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent disease. During recent years, increasing attention has been directed to the importance of the contribution of small airways in respiratory diseases. The small airways (usually defined as those with an internal diameter of \<2 mm) are recognized as the major site of resistance to airflow in obstructive lung disease. Although small airway disease is known in chronic airway diseases, the importance of small airway dysfunction on disease control, exacerbations and quality of life, and the importance of taking place among treatable targets is not clear. Therefore, our aim in the study is to determine the frequency of small airway dysfunction in COPD. Our secondary aim is to evaluate the role of small airway dysfunction in disease severity, disease phenotypes, disease control, quality of life and its effect on predicting the risk of exacerbation and its role among treatable targets in chronic airway diseases.

Conditions

• COPD
• Small Airway Disease

Interventions

DIAGNOSTIC_TEST

Impulse oscillometry

Impulse oscillometry is a pulmonary function test. During the test, the participant is told to breathe normally.

DIAGNOSTIC_TEST

Spirometric pulmonary function test

In the spirometric pulmonary function test, the participant is asked to perform respiratory maneuvers such as breathing deeply.

DIAGNOSTIC_TEST

Fractional exhaled nitric oxide (FENO) test

In the FENO test, the participant is asked to perform respiratory maneuvers such as breathing deeply.

DIAGNOSTIC_TEST

Thorax Computed Tomography

Computed tomography is a radiological examination.

DIAGNOSTIC_TEST

Chest X Ray

Chest X ray is a radiological examination.

DIAGNOSTIC_TEST

Blood eosinophil level

A tube of blood will be drawn from the participant.

OTHER

CAT

It consists of 8 questions.

OTHER

mMRC

It is the scale used to measure the severity of shortness of breath.

Sponsors & Collaborators

• Mersin University

  collaborator OTHER

• Sibel Naycı

  lead OTHER

Principal Investigators

• Sibel Nayci, Prof.Dr. · Mersin University, Department of Respiratory Diseases

• Demet Polat Yulug, Dr. · Mersin University, Department of Respiratory Diseases

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

SEQUENTIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-10-01

Primary Completion

2020-09-01

Completion

2021-04-01

Countries

• Turkey (Türkiye)

Study Locations