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Role of Regulatory B Cells in Behçet's Disease

NCT04376411 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 74

Last updated 2020-05-06

No results posted yet for this study

Summary

There are limited data about the role of regulatory B cells in Behcet Disease. In this study we aimed to identify the proportions of total B lymphocytes and their regulatory subset in different Behcet Disease phenotype and therapies concentrating on the cardiovascular system attempting to unravel their function in Behcet Disease.

Conditions

  • Behcet Disease

Interventions

DIAGNOSTIC_TEST

Flow-cytometric assay

100 µl of blood sample was incubated for 20 minutes at 4 C in the dark. Following incubation, red blood cells lysis, washing and analysis a specific software.Forward and side scatter histogram was used to define the lymphocytes population.

DIAGNOSTIC_TEST

2D Echocardiographic analysis

Trans thoracic echocardiographic examination was performed through (PHILIPS -33) echocardiography device with broadband S5-1 transducer

DIAGNOSTIC_TEST

Two-Dimensional speckle tracking echocardiography

Two-Dimensional speckle tracking echocardiography was performed on grey scale images of the left ventricle. For offline analysis digital storage software (Qlab 10.4) was used. The frame rate was adjusted to be 60-90 frame/second.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-12-15
Primary Completion
2019-03-30
Completion
2019-12-15

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04376411 on ClinicalTrials.gov