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Analysis of T- and B-Cell Subpopulations in Membranous Nephropathy

NCT05894512 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 44

Last updated 2026-03-03

No results posted yet for this study

Summary

The aim of this observational study is to provide analysis of T and B lymphocyte subgroups in peripheral blood samples of patients with primary membranous nephropathy (MN). A search for disease-related circulating antibodies \[anti-phospholipase A2 receptor antibody (anti-PLA2R) and anti-thrombospondin type 1 domain-containing 7A antibody (anti-THSD7A)\] in patients' sera is also planned.

The main questions to answer are:

1. What is the relationship of these cell populations and their distribution during follow-up with treatment, treatment responses, and relapses?
2. What is the relationship of the cell populations with anti-PLA2R (or anti-THSD7A) antibody levels?

Participants will provide peripheral venous blood samples at pre-designated regular intervals.

The research team will compare results of the primary MN group with two control groups (IgA nephropathy and healthy volunteer groups) to see if the findings are specific for primary MN.

Conditions

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Principal Investigators

  • Suzan Adin Cinar, PhD · Istanbul University

  • Safak Mirioglu, MD · Istanbul University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-06-01
Primary Completion
2026-02-15
Completion
2026-02-15

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05894512 on ClinicalTrials.gov