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Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation

NCT04365946 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2020-04-28

No results posted yet for this study

Summary

The aim of the study will be to analyze the microbiome in the blood and stomach in patients with intestinal metaplasia (IM) and / or gastric cancer (GC). As far as IM is concerned, it has been found that the incomplete type is related to GC mainly intestinal-type. Studies show differences in the microbiome in patients with IM and in patients with GC, but do not specify whether these differences are related to histological types.

Our intention is to further analyze the microbiome based on histological types. Most studies on stomach cancer have focused on the microbiota of gastric microbiota. Recent data have shown that the microbiome of the small intestine, especially the mucosa, can play a key role in the condition of the gastrointestinal tract. Disturbance of the microbiome of the small intestine has been found in celiac disease, chronic liver disease, diabetes and irritable bowel syndrome. However, information on the role of the microbiome in IM remains limited.

Conditions

Interventions

PROCEDURE

Gastroscopy

Upper GI endoscopy and biopsy

Sponsors & Collaborators

  • University of Ioannina

    collaborator OTHER

  • University Hospital, Ioannina

    lead OTHER

Principal Investigators

  • Konstantinos Vlachos, Prof · University of Ioannina

  • George Pappas-Gogos, Dr · University Hospital, Ioannina

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-18
Primary Completion
2020-09-14
Completion
2023-05-15

Countries

  • Greece

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04365946 on ClinicalTrials.gov