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Beige Fat, Energy, and the Natriuretic Peptide System

NCT04357964 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 137

Last updated 2024-08-01

Study results available
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Summary

Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases. NP levels differ by obesity status and race has not been established in humans. Thus, the investigators propose a study in which will quantify adipose tissue gene expression and energy expenditure in states of NP deficiency in humans. The overarching postulate is that obese and black individuals have NP deficiencies that contribute to less beige adipose tissue and lower energy expenditure.

Conditions

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    collaborator OTHER

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Alp Ikizler, MD · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-13
Primary Completion
2022-10-31
Completion
2022-10-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04357964 on ClinicalTrials.gov