Embryo Selection by Noninvasive Preimplantation Genetic Test

Summary

The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by comparing the differences of live birth rate, pregnancy rate and miscarriage rate between the two groups of embryo selection by "NICS+ morphology" and embryo selection only by "morphology" in IVF cycle.

Conditions

• Infertility
• Chromosome Abnormality

Interventions

DIAGNOSTIC_TEST

Non-invasive chromosome screening（NICS）

NICS is noninvasive chromosome screening approach to analysis the euploidy by free DNA in embryo culture medium

Sponsors & Collaborators

• Jinling Hospital, China

  collaborator OTHER

• Reproductive Medical Center of Hebei Maternity Hospital

  collaborator UNKNOWN

• Northwest Women's and Children's Hospital, Xi'an, Shaanxi

  collaborator OTHER

• The First Medical Center of Chinese People's Liberation Army General Hospital

  collaborator UNKNOWN

• Shengjing Hospital

  collaborator OTHER

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Reproductive & Genetic Hospital of CITIC-Xiangya

  collaborator OTHER

• Yikon Genomics Company, Ltd

  collaborator UNKNOWN

• Peking University Shenzhen Hospital

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• West China Second University Hospital

  collaborator OTHER

• Second Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Third Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Peking University Third Hospital

  lead OTHER

Principal Investigators

• Jie Qiao · Peking University Third Hospital

Study Design

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

42 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-04-16

Primary Completion

2024-02-28

Completion

2024-08-06

Countries

• China

Study Locations