Cumulative Live Birth Rate With eSET After Preimplantation Genetic Screening Versus Conventional In-vitro Fertilization

Summary

The purpose of this randomized clinical trial is to compare the efficacy and safety with transfer of embryos selected by next generation sequencing (NGS) versus conventional morphological criteria. Subjects with 3 or more blastocysts on day 5 of embryo culture will be randomized to the PGS or IVF group. A Freeze-all strategy and a single frozen blastocyst transfer will be performed in both PGS and IVF groups. The primary outcome is the cumulative live birth after transfers of up to 3 single blastocycsts in both groups.

Conditions

• Infertility

Interventions

PROCEDURE

blastocyst morphologic score

Blastocysts will be scored by Gardner morphologic criteria.

PROCEDURE

blastocyst biopsy and sequencing

Three blastocysts will be biopsied on trophectoderm, sequenced with next-generation sequencing (NGS). Euploidy will transferred one by one according to morphologic score.

PROCEDURE

freeze-all and single thawed blastocyst transfer

All blastocysts will be vitrified in fresh cycle. Single blastocyst will be thawed and transferred.

Sponsors & Collaborators

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• ShangHai Ji Ai Genetics & IVF Institute

  collaborator OTHER

• RenJi Hospital

  collaborator OTHER

• Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

  collaborator OTHER

• Suzhou Municipal Hospital

  collaborator OTHER

• Renmin Hospital of Wuhan University

  collaborator OTHER

• Yantai Yuhuangding Hospital

  collaborator OTHER

• Tang-Du Hospital

  collaborator OTHER

• Nanjing Maternity and Child Health Care Hospital

  collaborator OTHER

• Guangxi Maternal and Child Health Hospital

  collaborator OTHER

• Women's Hospital School Of Medicine Zhejiang University

  collaborator OTHER

• Guangdong Women and Children Hospital

  collaborator OTHER

• Tianjin Central Hospital of Gynecology Obstetrics

  collaborator OTHER

• Shengjing Hospital

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• Chen Zi-Jiang

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

37 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-09

Primary Completion

2020-06-30

Completion

2020-06-30

Countries

• China

Study Locations