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Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function

NCT04336852 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2

Last updated 2025-05-20

No results posted yet for this study

Summary

The goal of this study is to develop a test of cerebral vessel function by inducing a reactive hyperemia that will elicit a rapid and profound increase in cerebral vessel shear stress. The results of this project may lead to development of a test with prognostic/predictive utility for individual risk assessment of a future cerebrovascular event/disease. This information will be of vital importance to the medical community in regards to cerebrovascular health in aging individuals, and testing of interventions and therapies that may ameliorate these effects.

Conditions

  • Cerebrovascular Disorders
  • Cerebrovascular Disease

Interventions

PROCEDURE

Flow mediated dilation (brachial and femoral arteries)

Assessment of vascular function of the brachial and femoral arteries.

PROCEDURE

Cerebral vascular reactivity to carbon dioxide (CO2)

Cerebral blood flow responses to increasing partial pressure of CO2

PROCEDURE

Cerebral vascular function test

Cerebral blood flow responses to a reactive hyperemia stimulus

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Illinois at Chicago

    lead OTHER

Principal Investigators

  • Alexander J Rosenberg, PhD · University of Illinois at Chicago

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-14
Primary Completion
2023-05-12
Completion
2023-05-12

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04336852 on ClinicalTrials.gov