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The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke

NCT06354881 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2025-03-24

No results posted yet for this study

Summary

The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, identical to the first. This will allow us to look at any changes in brain blood flow from before management of risk factors and 4 weeks after management of risk factors.

Conditions

  • Lacunar Stroke

Interventions

DEVICE

Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres

TCD will be used to measure the cerebral blood flow in the middle and posterior cerebral arteries. This will be done at rest and during two sit-stand manoeuvres, whereby the participant will be asked to stand (from a seated position) and stay standing for 1 minute. The participant will then be given time to recover before repeating the manoeuvre. This will occur at the first visit and the follow-up visit 4 weeks after.

Sponsors & Collaborators

  • British Heart Foundation

    collaborator OTHER

  • University Hospitals, Leicester

    collaborator OTHER

  • University of Leicester

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-05-02
Primary Completion
2026-03-31
Completion
2026-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06354881 on ClinicalTrials.gov