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A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.

NCT04332809 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 208

Last updated 2020-04-03

No results posted yet for this study

Summary

A large retrospective study compared wound irrigation with antiseptic solution, with antimicrobial agent, and with normal saline in patients undergoing open appendectomy and concluded an evident superiority of antibiotic wound irrigation over both normal saline and antiseptic solution.

The present trial aimed to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution versus saline solution in prevention of incisional SSI after open appendectomy for acute appendicitis. We postulated that irrigation of every layer of the surgical wound separately would help reduce the incidence of incisional SSI by eradication of bacterial contamination of each layer which may occur during delivery, manipulation, and removal of the inflamed appendix through the McBurney's incision.

Conditions

  • Appendicitis

Interventions

PROCEDURE

saline-gentamicin irrigation

Layer-by-layer irrigation of the appendectomy wound will be performed using saline-gentamicin solution

PROCEDURE

saline irrigation

Layer-by-layer irrigation of the appendectomy wound will be performed using saline solution

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Sameh H Emile, M.D. · Mansoura University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2020-03-31
Completion
2020-04-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04332809 on ClinicalTrials.gov