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Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution

NCT04512196 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 102

Last updated 2022-05-25

No results posted yet for this study

Summary

This study is to evaluate the effectiveness of peritoneal lavage with super-oxidised solution in reducing surgical site infection after open surgery for perforated appendicitis.

Conditions

  • Perforated Appendicitis

Interventions

DRUG

Superoxidized Water

Super-oxidized solution contains hypochlorous acid (HOCl) which exhibits bactericidal activity. These reactive species create an imbalanced osmotic gradient which damages the cell membrane integrity of single celled organisms, and subsequently denaturing its lipid and protein content. Multicellular organisms including host tissue are not susceptible to such changes in osmolarity hence spared from damage.

DRUG

Normal Saline

Normal saline contains 0.9% sodium chloride.

Sponsors & Collaborators

  • Ministry of Health, Malaysia

    collaborator OTHER_GOV

  • Hospital Queen Elizabeth, Malaysia

    lead OTHER_GOV

Principal Investigators

  • Hari Sellappan, MB BCh BAO · Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
13 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-09
Primary Completion
2022-03-11
Completion
2022-04-11

Countries

  • Malaysia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04512196 on ClinicalTrials.gov