Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis

Summary

Research hypothesis:

Does delayed primary wound closure after appendectomy in adults with complicated appendicitis reduce postoperative superficial surgical site infection compare to primary wound closure.

Study design:

This study is a multicenter randomized controlled trial of delay versus primary wound closure in complicated appendicitis.

Setting:

Thammasat Hospital, Ramathibodi Hospital, Chonburi Hospital, Chonpratarn Hospital, Vachira Hospital, and Pathumthani Hospital

Participants:

Adult patients age 18 years or older and non-pregnant in women who have been diagnosed as gangrenous or ruptured appendicitis.

Outcome:

Superficial surgical site infection

Period of study:

August 2012 - August 2014

Conditions

• Surgical Site Infection

Interventions

PROCEDURE

Primary wound closure

A wound will be sutured immediately after the operative procedure uisng non-absorbable monofilament suture or stapler at intervals of one centimeter apart and 0.5 cm back from a wound edge.

Sponsors & Collaborators

• Thammasat Hospital

  collaborator UNKNOWN

• Chonburi hospital

  collaborator OTHER_GOV

• Vachira hospital

  collaborator UNKNOWN

• Pathumtani Hospital

  collaborator UNKNOWN

• Lampang Hospital

  collaborator OTHER

• Surin Hospital

  collaborator UNKNOWN

• Ramathibodi Hospital

  lead OTHER

Principal Investigators

• Boonying Siribumrungwong, MD · Ramathibodi Hospital

• Ammarin Thakkinstian, PhD · Ramathibodi Hospital

• Patarawan Woratanarat · Ramathibodi Hospital

• Borwornsom Leerapan · Ramathibodi Hospital

• Jittunut Hawanon · Thammasat Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-11-30

Primary Completion

2016-03-31

Completion

2016-03-31

Countries

• Thailand

Study Locations