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Comparison of Hypertonic Saline and Mannitol on Brain Relaxation During Supratentorial Tumors Resection

NCT04314674 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2020-03-19

No results posted yet for this study

Summary

Hyperosmotic agents are used to decrease intracranial pressure. The aim of the study is to compare the effects of continuous 3% hypertonic saline (HS), bolus HS and 20% mannitol on intraoperative brain relaxation in patients with raised intracranial pressure during surgery for supratentorial tumors.

Conditions

  • Brain Tumor - Metastatic
  • Brain Tumor, Adult: Glioblastoma

Interventions

DRUG

%3 HS bolus

After head fixation %3 HS bolus 3 ml/kg will be administered

DRUG

%3 HS infusion 20 ml/h

After head fixation %3 HS 20 ml/h infusion will be administered

DRUG

20% mannitol

After head fixation %20 mannitol 0.6 ml/kg will be administered

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Principal Investigators

  • Yusuf Tunali · Professor of the department

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-30
Primary Completion
2022-04-30
Completion
2022-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04314674 on ClinicalTrials.gov