MedTrace Logo

Effects of Different Types of General Anesthesia on Postoperative Pupillary Reactivity

NCT04307238 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 108

Last updated 2025-07-04

No results posted yet for this study

Summary

Objective: To compare the effects of volatile and intravenous anesthetics on pupillary function after general anesthesia using a portable infrared pupillometer.

Design: A monocentric, prospective, double blinded randomized study.

Patients: Patients who require elective Ear, Nose and Throat (ENT) surgery under general anesthesia.

Interventions: Patients undergoing elective ENT surgery will be assigned to intravenous versus inhalative anesthesia and pupillometric parameters monitored postoperative, using an infrared pupillometer.

Outcomes measures: Reported pupillometric parameters after intravenous and inhalative anesthesia.

The purpose of this study is to compare general anesthesia techniques (volatile, intravenous) on postoperative changes in pupillary reactivity by using infrared pupillometry.

Conditions

  • Pupillary Reflex Impaired

Interventions

DIAGNOSTIC_TEST

PLR

PLR measurements will be performed within the first 2 postoperative hours.

DIAGNOSTIC_TEST

Alertness testing

Preoperative (baseline) and every 30 minutes postoperative computer based alertness testing will be performed.

PROCEDURE

Propofol anesthesia

Maintenance of anesthesia will be performed using propofol.

PROCEDURE

Sevoflurane anesthesia

Maintenance of anesthesia will be performed using sevoflurane.

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-09
Primary Completion
2026-03-10
Completion
2026-03-10

Countries

  • Austria

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04307238 on ClinicalTrials.gov