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Transfusion Associated Dyspnea Profiling

NCT04267029 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 151

Last updated 2023-05-03

No results posted yet for this study

Summary

Transfusion reactions are defined as harms occurring during or after blood transfusion, with new heart/lung stress (eg. troubled breathing) regarded as cardiorespiratory transfusion reactions (CRTRs). CRTRs are among the most important, as the leading cause of transfusion-related harm and death. Though there are distinct classifications for these events, real life cases often don't fall neatly into a given category, with outliers regarded as "transfusion associated dyspnea (TAD)". It is unknown what TAD is -- whether it has a unique root cause, is a milder version of other known CRTRs, or is a blend of events. The purpose of this study is to better understand TAD and CRTRs by profiling them through a detailed medical history and more intensive laboratory assessment. This review of CRTRs may improve the quality/validity of final conclusions reported in the health record and to hemovigilance bodies, and uncover the nature of TAD and/or minimize CRTRs defaulting to the TAD category. Our enhanced understanding will advance diagnostic, treatment, and prevention efforts.

Conditions

  • Transfusion Reaction

Interventions

DIAGNOSTIC_TEST

TADPOL battery (deep clinicolaboratory profile)

profile dimensions: * hemolytic * allergic * cardiorenal * inflammatory * leukoagglutinating * exploratory bioarchive

Sponsors & Collaborators

  • University Health Network, Toronto

    collaborator OTHER

  • Sunnybrook Health Sciences Centre

    collaborator OTHER

  • MOUNT SINAI HOSPITAL

    collaborator OTHER

  • Unity Health Toronto

    collaborator OTHER

  • Canadian Blood Services

    collaborator OTHER

  • Toronto Transfusion Medicine Collaborative

    lead OTHER

Principal Investigators

  • Christine M Csert-Gazdewich, MD · Universith Health Network

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2022-10-04
Completion
2022-12-22

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04267029 on ClinicalTrials.gov