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Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response

NCT00159926 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2008-01-14

No results posted yet for this study

Summary

Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death. White blood cells in contact with the heart and lung machine and external surfaces release mediators partly responsible for this. Blood collected by the suction and the blood remaining in the heart and lung machine after its use, can be cleaned by a cell saver before reinfusion, and this might reduce the inflammatory response.

Conditions

  • Systemic Inflammatory Response Syndrome
  • Coronary Arteriosclerosis

Interventions

PROCEDURE

Cell saver

Cell saver intraoperatively for coronary artery bypass grafting using cardiopulmonary bypass

PROCEDURE

No cell saver

Conventional suction for coronary artery bypass grafting using cardiopulmonary bypass

Sponsors & Collaborators

  • Danish Heart Foundation

    collaborator OTHER

  • Copenhagen Hospital Corporation

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Sune Damgaard, MD · Dept. of Cardiothoracic Surgery, Rigshospitalet, Copenhagen

  • Daniel A Steinbrüchel, Professor · Dept. of Cardiothoracic Surgery, Rigshospitalet, Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-01-31
Completion
2004-02-29

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00159926 on ClinicalTrials.gov