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Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation?

NCT02897739 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 77

Last updated 2019-05-08

No results posted yet for this study

Summary

Tako Tsubo Cardiomyopathy (TTC), also known as "Broken Heart Syndrome", is a disorder of the heart that occurs most commonly in women (although it occasionally occurs in men) and is usually related to a stressful event. Symptoms are often similar to a heart attack, and include chest pain and shortness of breath. Although Tako Tsubo Cardiomyopathy is not a new medical condition, it has not been widely recognised until the last decade. Currently the investigators don't have an exact understanding of how or why the heart is affected in this way, and so the investigators are conducting a study to help understand what causes Tako Tsubo Cardiomyopathy.

Conditions

  • Tako-tsubo Cardiomyopathy

Interventions

BIOLOGICAL

Acute Inflammatory Activation study

Blood sampling for exploration of type and level of inflammatory response

RADIATION

PET CT

PET study for metabolic pathway study

BEHAVIORAL

Psychological assessment

Assessment by a psychologist

PROCEDURE

Magnetic resonance imaging

Cardiac MRI and short MRI following USPIO infusion

Sponsors & Collaborators

  • NHS Grampian

    collaborator OTHER_GOV

  • University of Aberdeen

    lead OTHER

Principal Investigators

  • Dana Dawson, MD, MRCP · University of Aberdeen

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2019-03-31
Completion
2019-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02897739 on ClinicalTrials.gov