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Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda

NCT04230161 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3502

Last updated 2023-01-25

No results posted yet for this study

Summary

The use of insecticide-treated bed nets (ITNs) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance in mosquito populations to commonly used insecticides. Newly developed, next-generation ITNs using two insecticides or an insecticide synergist and an insecticide are effective against resistant mosquitoes, but large-scale uptake of these nets has been slow due to higher costs and lack of enough evidence to support broad policy recommendations.

This observational study will occur alongside a pilot distribution of next-generation ITNs and collect data over three years on their entomological and epidemiological impact as well as anthropological factors that influence their uptake and use. Enhanced data collection will occur in three districts: one district that will receive Interceptor G2 ® ITN (BASF) and two comparator districts, one that will receive standard pyrethroid-only ITNs and one that will receive standard pyrethroid-only ITNs and indoor residual spraying (IRS). Data will be collected on malaria vector bionomics, disease epidemiology, and human behaviors in order to help better demonstrate the public health value of next-generation ITNs and to support donors, policymakers, and National Malaria Control Programs in their ITN decision-making and planning processes.

Conditions

Interventions

OTHER

Standard long-lasting insecticidal net

Yahe LN (Yamei Industry) contains a pyrethroid insecticide.

OTHER

Chlorfenapyr insecticide treated net

Interceptor G2® (BASF) is an ITN containing two active ingredients: Alpha-cypermethrin, a pyrethroid insecticide, and chlorfenapyr, a pyrrole insecticide.

OTHER

Indoor residual spraying

Fludora Fusion (Bayer Vector Control) is a spray containing two active ingredients: clothianidin, a neonicotinoid insecticide, and deltamethrin, a pyrethroid insecticide.

Sponsors & Collaborators

  • Rwanda Biomedical Centre

    collaborator OTHER

  • University of Rwanda

    collaborator OTHER

  • Liverpool School of Tropical Medicine

    collaborator OTHER

  • PATH

    lead OTHER

Principal Investigators

  • Joseph Wagman, PhD · PATH

  • Aimable Mbituyumuremyi, MD · Rwanda Biomedical Centre

Eligibility

Min Age
6 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-02-24
Primary Completion
2022-11-18
Completion
2022-11-18

Countries

  • Rwanda

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04230161 on ClinicalTrials.gov