Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets

Summary

The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries. This progress is threatened by the wide scale selection of insecticide resistant malaria vectors. New types of LLIN combining a mixture of two insecticides or an insecticide and a synergist have been developed to control resistant mosquitoes.

The efficacy of three bi-treated LLIN are compared to a standard LLIN in a four-arm, single blinded, cluster-randomized trial in Misungwi district, Tanzania. The arms are; 1/ Royal Guard, a net combining pyriproxyfen (PPF), which is known to disrupt female reproduction and fertility of eggs, and the pyrethroid alpha-cypermethrin, 2/Interceptor G2, LLIN incorporating a mixture of two adulticides with different modes of action; chlorfenapyr and a pyrethroid (alpha-cypermethrin), and 3/ Olyset Plus an LLIN which incorporates a synergist, piperonyl butoxide (PBO), to enhance the potency of pyrethroid insecticides, and 4/ The control arm: Interceptor treated a standard LLIN treated with alpha-cypermethrin.

The primary outcome of the trial will be cross-sectional community prevalence of malaria infection (by RDT) in children aged 6 months to 14 years at 12 and 24 months post-intervention.

Conditions

• Malaria
• Anaemia

Interventions

OTHER

Chlorfenapyr LLIN

Dual active ingredient Long Lasting Insecticidal Net

OTHER

pyriproxyfen LLIN

Dual active ingredient Long Lasting Insecticidal Net

OTHER

Piperonyl butoxide LLIN

Combination insecticide and synergist Long Lasting Insecticidal Net

OTHER

Standard LLIN

Standard Long Lasting Insecticidal Net with one insecticide

Sponsors & Collaborators

• Kilimanjaro Christian Medical Centre, Tanzania

  collaborator OTHER

• National Institute for Medical Research, Tanzania

  collaborator OTHER_GOV

• University of Ottawa

  collaborator OTHER

• London School of Hygiene and Tropical Medicine

  lead OTHER

Principal Investigators

• Natacha Protopopoff, Phd · London School of Hygiene and Tropical Medicine

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

6 Months

Max Age

14 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-02-01

Primary Completion

2022-02-28

Completion

2023-02-01

Countries

• Tanzania

Study Locations