MedTrace Logo

Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso

NCT04157894 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5606

Last updated 2022-12-13

No results posted yet for this study

Summary

The use of insecticide-treated bed nets (ITN) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance commonly used insecticides in mosquito populations. Newly developed, next-generation ITNs using two insecticides or an insecticide synergist and an insecticide are effective against resistant mosquitoes, but large-scale uptake of these nets has been slow due to higher costs and lack of enough evidence to support broad policy recommendations.

This observational study will occur alongside a pilot distribution of next-generation ITNs and collect data over three years on their entomological and epidemiological impact as well as anthropological factors that influence their uptake and use. Data collection will occur in three districts: one receiving dual-active ingredient ITNs, Interceptor® G2 (BASF), one receiving a standard pyrethroid long-lasting insecticidal net (LLIN), Interceptor® (BASF), and one receiving PermaNet®3.0 (Vestergaard) an LLIN containing an insecticide and an insecticide synergist. Data will be collected on malaria vector bionomics, disease epidemiology, and human behaviors in order to help better demonstrate the public health value of next-generation ITNs and to support donors, policymakers, and National Malaria Control Programs in their ITN decision-making and planning processes.

Conditions

Interventions

OTHER

Standard long-lasting insecticidal net

Interceptor® (BASF) contains a pyrethroid insecticide

OTHER

Chlorfenapyr insecticide treated net

Interceptor® G2 (BASF) is an ITN containing two active ingredients: Alpha-cypermethrin, a pyrethroid insecticide, and chlorfenapyr, a pyrrole insecticide.

OTHER

Piperonyl butoxide long-lasting insecticidal net

PermaNet®3.0 (Vestergaard) contains deltamethrin, a pyrethroid insecticide, and piperonyl butoxide, an insecticide synergist.

Sponsors & Collaborators

  • Centre national de recherche et de formation sur le paludisme

    collaborator OTHER_GOV

  • Liverpool School of Tropical Medicine

    collaborator OTHER

  • PATH

    lead OTHER

Principal Investigators

  • Joseph Wagman, PhD · PATH

  • Sagnon NFalé, MD · Centre national de recherche et de formation sur le paludisme

Eligibility

Min Age
6 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-07-07
Primary Completion
2022-07-06
Completion
2022-07-06

Countries

  • Burkina Faso

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04157894 on ClinicalTrials.gov