Thrombus Aspiration in STEMI Patients With High Thrombus Burden

Summary

This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included. Patients are randomized to be treated with or without manual thrombus aspiration(TA) during primary percutaneous coronary intervention(PPCI) by a ratio of 1:1.

Conditions

• ST-segment Elevation Myocardial Infarction (STEMI)

Interventions

PROCEDURE

Thrombus aspiration

Percutaneous Coronary Intervention with manual aspiration thrombectomy

PROCEDURE

PCI Alone

Percutaneous Coronary Intervention without manual aspiration thrombectomy

Sponsors & Collaborators

• Zhongshan People's Hospital, Guangdong, China

  collaborator OTHER

• Kaiping Central Hospital

  collaborator OTHER

• Second Affiliated Hospital of Shantou University Medical College

  collaborator OTHER

• The Third Xiangya Hospital of Central South University

  collaborator OTHER

• Sihui City People's Hospital

  collaborator UNKNOWN

• Shenzhen Baoan District Shiyan People's Hospital

  collaborator UNKNOWN

• People's Hospital of Nanxiong County

  collaborator UNKNOWN

• Yuebei People's Hospital

  collaborator OTHER

• Weifang Medical University

  collaborator OTHER

• Wuzhou Gongren Hospital

  collaborator UNKNOWN

• Dafeng Hospital of Chaoyang District in Shantou City

  collaborator UNKNOWN

• Shenzhen Baoan People's Hospital

  collaborator UNKNOWN

• Dongguan People's Hospital

  collaborator OTHER_GOV

• Yangchun People's Hospital

  collaborator UNKNOWN

• Taishan People's Hospital

  collaborator UNKNOWN

• The Second People's Hospital of Foshan

  collaborator OTHER

• Guangzhou Hospital of integrated Traditional and West Medicine

  collaborator UNKNOWN

• Guangning People's Hospital

  collaborator UNKNOWN

• Foshan Sanshui District People's Hospital

  collaborator UNKNOWN

• Qingyuan People's Hospital

  collaborator OTHER

• Luhe County People's Hospital

  collaborator UNKNOWN

• People's Hospital of Xinjiang Uygur Autonomous Region

  collaborator OTHER

• The Fourth People's Hospital of Chenzhou

  collaborator UNKNOWN

• People's Hospital of Dapu County

  collaborator UNKNOWN

• Shenzhen People's Hospital

  collaborator OTHER

• Heyuan people's Hospital

  collaborator UNKNOWN

• Huaiji People's Hospital

  collaborator UNKNOWN

• People's Hospital of Yingde City

  collaborator UNKNOWN

• Qingyuan Hospital of Traditional Chinese Medicine Affiliated To Guangzhou University of Traditional Chinese Medicine

  collaborator UNKNOWN

• Zhongshan Hospital Of Traditional Chinese Medicine

  collaborator OTHER

• The Third Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• Lianzhou People's Hospital

  collaborator UNKNOWN

• Lianping Xian Ren Ming Yi Yuan

  collaborator UNKNOWN

• Guangxi Zhuang Autonomous Region Nationalities Hospital

  collaborator UNKNOWN

• Liuzhou Municipal Liutie Central Hospital

  collaborator UNKNOWN

• Chen Zhou 3RD People's Hospital

  collaborator UNKNOWN

• Longgang District People's Hospital of Shenzhen

  collaborator OTHER

• The Affiliated Shunde Hospital of Jinan University

  collaborator UNKNOWN

• Shenzhen Longhua District Central Hospital

  collaborator UNKNOWN

• Shantou Central Hospital

  collaborator OTHER

• Tongxiang First People's Hospital

  collaborator UNKNOWN

• Bobai County People's Hospital, Guangxi

  collaborator UNKNOWN

• Meizhou Traditional Chinese Medicine Hospital

  collaborator UNKNOWN

• The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital

  collaborator UNKNOWN

• Shenzhen Third People's Hospital

  collaborator OTHER

• Yangjiang People's Hospital

  collaborator OTHER

• Jiangmen Central Hospital

  collaborator OTHER

• Eighth Affiliated Hospital, Sun Yat-sen University

  collaborator OTHER

• The First People's Hospital of Kashgar Erea

  collaborator UNKNOWN

• First People's Hospital of Foshan

  collaborator OTHER

• Zhaoqing Gaoyao People's Hospital

  collaborator UNKNOWN

• People's Hospital of Nanhai District, Foshan

  collaborator UNKNOWN

• The Second Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• Nanning Second People's Hospital

  collaborator OTHER

• The Second People's Hospital of Nanhai District of Foshan

  collaborator UNKNOWN

• Shangyou People's Hospital

  collaborator UNKNOWN

• Guangdong Provincial People's Hospital

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-30

Primary Completion

2025-08-31

Completion

2026-02-28

Countries

• China

Study Locations