Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy

Summary

Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel occlusive cerebral infarction, but 20-50% of patients still experience ineffective revascularization. Therefore, postoperative monitoring and treatment of patients with large vessel occlusions is crucial for early recognition, management and prevention of complications. Stress ulcer bleeding is a serious complication after acute ischemic stroke, with a prevalence of 1%-5%, and a previously proven incidence of stress ulcer bleeding after ischemic stroke. Stress ulcer bleeding after ischemic stroke has been shown to be closely associated with unfavorable outcomes, such as mortality. Current national and international guidelines or consensus on the prevention of stress ulcers after acute ischemic stroke do not advocate the routine use of histamine receptor antagonists or proton pump inhibitors for the prevention of stress ulcers, but rather should be considered in the context of the patient's risk factors for stress ulcers and discontinued after the patient initiates enteral nutrition. However, there is no evidence-based medical evidence to support the risk-benefit relationship of stress ulcer drug prophylaxis in patients with mechanical thrombectomy for acute anterior circulation large vessel occlusion.

Conditions

• Acute Ischemic Stroke

Sponsors & Collaborators

• Guangzhou Medical University

  collaborator OTHER

• The Affiliated Hospital of Inner Mongolia Medical University

  collaborator OTHER

• Second Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Second Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Fujian Medical University Union Hospital

  collaborator OTHER

• Huizhou Municipal Central Hospital

  collaborator OTHER

• Haikou People's Hospital

  collaborator OTHER

• Kashgar 1st People's Hospital

  collaborator OTHER

• Ganzhou City People's Hospital

  collaborator OTHER

• Guangdong Provincial Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Huadu District People's Hospital of Guangzhou

  collaborator OTHER

• Dongguan donghua hospital

  collaborator UNKNOWN

• Sinopharm North Hospital

  collaborator UNKNOWN

• Heyuan people's Hospital

  collaborator UNKNOWN

• Hainan People's Hospital

  collaborator OTHER

• Hainan Traditional Chinese Medicine Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

  collaborator OTHER

• The Second Hospital University of South China

  collaborator OTHER

• Dongguan People's Hospital

  collaborator OTHER_GOV

• Yueyang People's Hospital

  collaborator UNKNOWN

• Nanfang Hospital, Southern Medical University

  lead OTHER

Principal Investigators

• Suyue Pan · Department of Neurology, Nanfang Hospital,Southern Medical University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-05-01

Primary Completion

2027-01-01

Completion

2027-01-01

Countries

• China

Study Locations