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Progression and Etiology of Cortical Porosity in Diabetic Bone Disease

NCT04208230 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 96

Last updated 2023-11-18

No results posted yet for this study

Summary

Type 2 diabetes is associated with increased cortical bone porosity and increased fracture risk. The goal of this proposed study is to understand the longitudinal evolution of cortical bone porosity and to investigate the underlying biological processes that drive increased cortical porosity and fracture risk in the setting of diabetes. The investigators will apply novel techniques for in vivo imaging of cortical pores to patients with type 2 diabetes and controls in a longitudinal prospective study. This work will establish the longitudinal progression of cortical porosity and determine whether pore content can serve as a predictor of future cortical degradation and bone fragility.

Conditions

Interventions

DEVICE

XtremeCT

HRpQCT technology provides information on bone microarchitecture, bone density and bone strength by measuring the cortical and trabecular bone structures with improved spatial resolution and defining the surfaces in three-dimensional manner.

Sponsors & Collaborators

Principal Investigators

  • Galateia Kazakia, PhD · University of California, San Francisco

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-03
Primary Completion
2022-12-31
Completion
2023-11-15
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04208230 on ClinicalTrials.gov