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Development of Cellular Models for Osteoblast Response Study to Adipocytic Secretions in an Osteoporosis Context.

NCT04377880 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2025-12-23

No results posted yet for this study

Summary

The recent studies suggest that secretions from medullary adipocytes are involved in the mechanisms of bone loss in osteoporosis (OP) through their actions on neighbouring osteoforming cells, the osteoblasts. The objective of the research is the development of new cellular models representing the aging skeleton to confirm this hypothesis. To this end, osteoblasts will be isolated from human bone fragments coming from femoral heads discarded during total hip replacement surgery. The osteoblastic response to secreted factors released from medullary adipocytes of commercial origin will be analysed using conditioned media incubations. This phenotypic response will be quantified for each subject through the analysis of gene expression levels. Inter-subject phenotype variations will be related to bone density and microarchitecture data obtained by X-ray microtomography. This will assess the existence of a correlation between the osteoblast response to adipocyte secretions and the degree of osteoporosis of the subject from whom the cells are derived.

Conditions

Sponsors & Collaborators

  • Universite du Littoral Cote d'Opale

    collaborator OTHER

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Eric FODZO, MD · University Hospital, Lille

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-15
Primary Completion
2024-09-04
Completion
2024-09-04

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04377880 on ClinicalTrials.gov