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Autophagy Maintains Vascular Function Through a Novel Glycolysis-linked Pathway Regulating eNOS

NCT04200560 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2022-08-22

No results posted yet for this study

Summary

Aging is inevitable and is the primary risk factor for developing cardiovascular disease. The molecular mechanisms that drive vascular dysfunction in the context of aging are incompletely understood. The overall hypothesis is that the age-related decline in endothelial cell (EC) autophagy leads to arterial dysfunction. This study will determine whether physiological shear-stress affects autophagosome formation and nitrous oxide (NO) generation in ECs.

Conditions

  • Vascular Diseases

Interventions

OTHER

Rhythmic Handgrip Exercise

60 minute rhythmic handgrip exercise

OTHER

Chronic Exercise Training

Handgrip exercise training consisting of three 60-minute training sessions per week for eight weeks.

Sponsors & Collaborators

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2022-05-30
Completion
2022-05-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04200560 on ClinicalTrials.gov