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Genetic Mutation in Recurrent Cervical Cancer

NCT04191226 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2019-12-20

No results posted yet for this study

Summary

Little is known about the characteristics of genetic mutation in recurrent cervical cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy and immunotherapy.

Conditions

  • Recurrent Cervical Cancer
  • Nucleotide Variant
  • Copy Number Variation
  • Insertion-deletion Variation
  • Genomic Structural Variation
  • Total Mutation Burden
  • Microsatellite Instability
  • PD-1
  • PD-L1

Interventions

DIAGNOSTIC_TEST

Multi-gene panel testing

A multi-gene panel, which consists of more than 500 hundred genes will be provided for mutation analysis

Sponsors & Collaborators

  • Lei Li

    lead OTHER

Principal Investigators

  • Lei Li · Peking Union Medical College Hospital

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-12-19
Primary Completion
2022-01-01
Completion
2023-01-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04191226 on ClinicalTrials.gov