HPV Infection and Genital Microecology of Childbearing-age Female in China: A Cohort and Multicenter Study

Summary

The purpose of this study to access the relations between genital microecology, HPV infection and cervical intraepithelial neoplasia of childbearing-age female in China

Conditions

• Papillomavirus Infections
• Uterine Cervical Neoplasms
• Sexual Transmitted Disease

Interventions

DIAGNOSTIC_TEST

16S rRNA gene sequencing of cervical secretions

1. 16S rRNA gene sequencing of vaginal secretions: using NGS technology to assess the microbiota of the vaginal secretions 2. Microecology assessment of vaginal secretions: morphology test, functional assessment and Nugent score assessment of the vaginal secretions are included. 3. Genotyping of HPV and detection of sexually transmitted diseases pathogens based on the cervical exfoliated cells 4. Thinprep cytologic test of cervical exfoliated cells: to evaluate the grade of cervical intraepithelial neoplasia

Sponsors & Collaborators

• Peking University First Hospital

  collaborator OTHER

• The Affiliated Hospital Of Guizhou Medical University

  collaborator OTHER

• Hainan General Hospital

  collaborator OTHER

• LanZhou University

  collaborator OTHER

• Lianyungang Hospital Affiliated Bengbu Medical College

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Jinan Central Hospital

  collaborator OTHER

• Tibet Autonomous Region People's Hospital

  collaborator OTHER

• The Affiliated Hospital Of Southwest Medical University

  collaborator OTHER

• Anhui Provincial Hospital

  collaborator OTHER_GOV

• The First People's Hospital of Zunyi

  collaborator OTHER

• The Third Affiliated Hospital of Southern Medical University

  collaborator OTHER_GOV

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Zhuhai Center for Maternal and Child Health Care

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Qinghai Red Cross Hospital

  collaborator OTHER

• Changzhi People's Hospital

  collaborator OTHER

• Shanghai East Hospital

  collaborator OTHER

• Fifth Affiliated Hospital of Guangzhou Medical University

  collaborator OTHER

• Huizhou Municipal Central Hospital

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  collaborator OTHER

• Yuebei People's Hospital

  collaborator OTHER

• The Seventh Affiliated Hospital of Sun Yat-sen University

  collaborator OTHER

• Fujian Maternity and Child Health Hospital

  collaborator OTHER

• The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• The Fifth Affiliated Hospital of Southern Medical University

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• First Hospital of China Medical University

  collaborator OTHER

• Gansu Provincial Hospital

  collaborator OTHER

• Zhujiang Hospital

  lead OTHER

Principal Investigators

• Hongwei Zhou, Doctor · Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-11-12

Primary Completion

2024-12-31

Completion

2024-12-31

Countries

• China

Study Locations