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Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition

NCT04174820 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 145

Last updated 2020-11-19

No results posted yet for this study

Summary

One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.

Conditions

  • Medulloblastoma, Childhood
  • Healthy Volunteers
  • Fossa Posterior Tumor
  • Low-grade Glioma

Interventions

OTHER

Functional Magnetic Resonance Imaging (fMRI)

list of the tests: Box and Blocks test, Nine Hole Peg test, walkway GAITRite, EXALang tests, NEPSY II subtests, BRIEF, FEE, WISC 5 tests

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    collaborator OTHER

  • National Cancer Institute, France

    collaborator OTHER_GOV

  • University Hospital, Angers

    lead OTHER_GOV

Principal Investigators

  • Mickaël Dinomais, MD · University Hospital, Angers

Eligibility

Min Age
6 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-12
Primary Completion
2022-11-01
Completion
2022-11-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04174820 on ClinicalTrials.gov