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Measuring Fatty Acid Oxidation in Gliomas Using 18F-FPIA PET/MRI

NCT04097535 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 11

Last updated 2024-11-21

Study results available
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Summary

Glioma is the most common primary malignant brain tumour in adults and has an extremely poor prognosis. The aim of this study is to quantify the degree of early step fatty acid oxidation in gliomas as imaged by 18F-FPIA PET/MRI in 10 evaluable patients.

The Investigators hypothesise that FPIA uptake will be higher in high-grade gliomas compared to lower grade gliomas, in keeping with a higher propensity of high grade tumours to generate ATP and NADPH via fatty acid oxidation under bioenergetic stress.

Conditions

Interventions

OTHER

PET/MRI

Imaging scan

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Matthew Williams, MBChB · Imperial College Healthcare NHS Trust

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-06
Primary Completion
2020-08-07
Completion
2020-08-07

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04097535 on ClinicalTrials.gov