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Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients

NCT05697666 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 33

Last updated 2023-01-26

No results posted yet for this study

Summary

Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory mechanics by reducing ventilator induced lung injuries (VILI), especially the so called atelectrauma. Although its monitoring is recommended in clinical practice, data about the depth of NMB necessary for an effective relaxation of the thoracic and diaphragmatic muscles and, therefore, the reduction of the chest wall elastance, are scarce. The investigators hypothesised that complete versus partial NMB can modify respiratory mechanics and its partitioning.

Conditions

  • Acute Respiratory Distress Syndrome
  • Ventilator-Induced Lung Injury

Interventions

OTHER

Modulation of the depth of the neuromuscular blockade

Analysis of the respiratory mechanics at two times: * Facial train of four = 0, indicating a deep neuromuscular blockade * Facial train of four \> 0, indicating a intermediate to light neuromuscular blockade

Sponsors & Collaborators

  • Centre Hospitalier de Saint-Brieuc

    lead OTHER

Principal Investigators

  • Nicolas BARBAROT, MD · Centre Hospitalier Saint Brieuc

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-01
Primary Completion
2022-02-01
Completion
2022-02-28

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05697666 on ClinicalTrials.gov