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A Longitudinal Study of Inflammatory Pathways in Depression

NCT04159207 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2025-04-06

No results posted yet for this study

Summary

Suicide accounts for at least 1 million deaths globally each year. This is likely a significant underestimate, because suicide is under-reported in many countries. In the US, over 42,000 people die from suicide annually. Despite increased focus on identification and treatment, the rate of suicide has increased steadily over the past 15 years.

Our project aims both to improve our understanding of factors that increase the risk for suicide by comparing blood biomarkers associated with inflammation in patients with depression without suicidal behavior and patients with depression and suicidal behavior. The 160 individuals in this study will be followed with psychiatric assessments and blood samples at repeated time points over one year.

Conditions

Sponsors & Collaborators

  • Pine Rest Christian Mental Health Services

    collaborator OTHER

  • Columbia University

    collaborator OTHER

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Van Andel Research Institute

    lead OTHER

Principal Investigators

  • Lena C Brundin, M.D.; Ph.D. · Van Andel Research Institute

  • Eric Achtyes, M.D. · Pine Rest Christian Mental Health Services

  • Joseph Mann, M.D. · Columbia University Health Sciences

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-10-01
Primary Completion
2023-08-30
Completion
2023-08-30

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04159207 on ClinicalTrials.gov