the Effect of Different Drugs and Infusion Ways on Degree of Postoperative Comfort

Summary

To explore the effect of different drugs and infusion ways on degree of postoperative comfort.Patients undergoing spinal neoplasm surgery receive different patient controlled analgesia(PCA) drugs postoperatively,one group is sufentanil,the other is hydromorphone. Then each drug group will be divided into two subgroups according to the infusion way,intravenously,subcutaneously. During the patient controlled analgesia period, patients' degree of comfort,pain score,sleep quality, the degree of side reaction will be recorded.

Conditions

• Analgesia, Patient-Controlled

Interventions

DRUG

intravenous sufentanil

The PCA pumps contain sufentanil . And the pump is connected to participants intravenously .

DRUG

subcutaneous sufentanil

The PCA pumps contain sufentanil. And the pump is connected to participants subcutaneously.

DRUG

intravenous hydromorphone

The PCA pumps contain hydromorphone. And the pump is connected to participants intravenously .

DRUG

subcutaneous hydromorphone

The PCA pumps contain hydromorphone. And the pump is connected to participants subcutaneously.

DRUG

intravenous sufentanil and dexmedetomidine

The PCA pumps contain sufentanil and dexmedetomidine. And the pump is connected to participants intravenously .

DRUG

subcutaneous sufentanil and dexmedetomidine

The PCA pumps contain sufentanil and dexmedetomidine. And the pump is connected to participants subcutaneously.

DRUG

intravenous hydromorphone and dexmedetomidine

The PCA pumps contain hydromorphone and dexmedetomidine. And the pump is connected to participants intravenously.

DRUG

subcutaneous hydromorphone and dexmedetomidine

The PCA pumps contain hydromorphone and dexmedetomidine. And the pump is connected to participants subcutaneously

Sponsors & Collaborators

• Jun Wang

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-10-08

Primary Completion

2020-09-30

Completion

2020-10-30

Countries

• China

Study Locations