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Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery

NCT04421209 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2021-03-16

No results posted yet for this study

Summary

The purpose of this study is to determine if treatment with low-dose oral propranolol in the days before and after surgery decrease postoperative pain and improve pain scores.

Conditions

  • Lumbar Disc Disease
  • Spinal Fusion
  • Degenerative Disc Disease

Interventions

DRUG

Propranolol Hcl 40mg Tab

40mg PO BID for the three days prior to surgery, 40mg PO BID the day of surgery and on post-op days 1 and 2.

DRUG

Placebo oral tablet

Placebo tablets administered with the same schedule of Propranolol tablets

Sponsors & Collaborators

  • Foundation for Anesthesia Education and Research

    collaborator OTHER

  • Duke University

    lead OTHER

Principal Investigators

  • Thomas Buchheit, MD · Department of Anesthesiology, Duke University

  • Stephan Frangakis, MD/PhD · Department of Anesthesiology, Duke University

  • William Maixner, DDS/PhD · Department of Anesthesiology, Duke University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-31
Primary Completion
2021-06-30
Completion
2021-09-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04421209 on ClinicalTrials.gov