The GBA Multimodal Study in Parkinson's Disease

Summary

This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the GBA gene, with and without Parkinson's disease. The ingestigators will also use a technology-based assessment to study the typing patterns as possible biomarkers of early motor dysfunctions.

Conditions

• Parkinson Disease
• GBA Gene Mutation
• Gaucher Disease

Interventions

DIAGNOSTIC_TEST

PET scan

3 PET scans to analyze the dopamine metabolism, acetylcholine and tau protein deposition in the brain.

DIAGNOSTIC_TEST

neuroQWERTY

Analysis of free-text typing in a computer and/or a touch-screen device.

Sponsors & Collaborators

• University of British Columbia

  collaborator OTHER

• University of Washington

  collaborator OTHER

• Oregon Health and Science University

  collaborator OTHER

• Simon Fraser University

  collaborator OTHER

• Michael J. Fox Foundation for Parkinson's Research

  collaborator OTHER

• Silverstein Foundation

  collaborator UNKNOWN

• Weston Brain Institute

  collaborator OTHER

• Pacific Parkinson's Research Centre

  lead OTHER

Principal Investigators

• Michele Matarazzo, MD · Pacific Parkinson's Research Centre | University of British Columbia

• A. Jon Stoessl, CM, MD, FRCPC, FCAHS · Pacific Parkinson's Research Centre | University of British Columbia

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-05-01

Primary Completion

2025-12-30

Completion

2025-12-30

Countries

• United States
• Canada

Study Locations