Apatinib for Advanced Non-squamous Head and Neck Cancer
NCT02989259 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2016-12-13
Summary
In this study, the investigators try to evaluate the efficacy and safety of apatinib in advanced non-squamous head and neck cancer and to validate the correlative biomarkers.
Conditions
- Head and Neck Neoplasms
Interventions
- DRUG
-
Apatinib
apatinib 500mg p.o. qd
Sponsors & Collaborators
-
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
lead OTHER
Principal Investigators
-
Xiaohui He, B.D. · Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-12-31
- Primary Completion
- 2018-12-31
- Completion
- 2021-12-31
Countries
- China
Study Locations
More Related Trials
-
Research of Biomarkers of Activity and Efficacy of BIBW2992 in Untreated Non-metastatic HNSCC Patients
NCT01415674 ·Status: COMPLETED ·Phase: PHASE2
-
First-line Chemotherapy for Recurrent Cervical Cancer
NCT04188847 ·Status: COMPLETED ·Phase: PHASE2
-
SHR-1210 in Combination With Apatinib in Patients With Metastatic, Persistent, or Recurrent Cervical Cancer
NCT03816553 ·Status: COMPLETED ·Phase: PHASE2
-
A Prospective Randomized Trial of Capecitabine Treatment in Patients With HNSCC
NCT03678649 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer
NCT01783587 ·Status: COMPLETED ·Phase: PHASE1
-
Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study)
NCT03695510 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of PD-1 Plus Chemotherapy in Poorly Differentiated Locally Advanced (LA) HNSCC
NCT06100497 ·Status: RECRUITING ·Phase: PHASE2
-
LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy
NCT02131155 ·Status: TERMINATED ·Phase: PHASE3
-
Biomarker-based Study in R/M SCCHN
NCT03088059 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma
NCT07105592 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck
NCT01427478 ·Status: COMPLETED ·Phase: PHASE3
-
A Prospective, Multicenter, Multicohort Phase II Study: Evaluating the Efficacy and Safety of Preoperative Neoadjuvant Treatment With a PD-1 Inhibitor in Combination With Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
NCT06894459 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma
NCT05494190 ·Status: RECRUITING ·Phase: NA
-
LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy
NCT01345682 ·Status: COMPLETED ·Phase: PHASE3
-
Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck
NCT01044433 ·Status: COMPLETED ·Phase: PHASE2
-
Single-agent Capecitabine as Metronomic Chemotherapy in LAHNSCC (CMHN)
NCT05044117 ·Status: RECRUITING ·Phase: PHASE3
-
Sufficient Chemotherapy Combine With Maintenance Chemotherapy in the Treatment of Oligometastatic Nasopharyngeal Carcinoma
NCT04319471 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC
NCT05516589 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of APG-157 in Head and Neck Cancer
NCT05312710 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy
NCT01856478 ·Status: COMPLETED ·Phase: PHASE3
-
LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy
NCT01345669 ·Status: TERMINATED ·Phase: PHASE3
-
SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
NCT00095628 ·Status: COMPLETED ·Phase: PHASE2
-
Study of SCB01A in Patient With Head and Neck Cancer
NCT02488629 ·Status: TERMINATED ·Phase: PHASE2
-
Efficacy and Safety Study of Oxaliplatin/5-FU in Patients With Recurrent or Metastatic Head and Neck Cancer
NCT01370876 ·Status: TERMINATED ·Phase: PHASE2
-
Efficacy of Sr-89 for Differentiated Thyroid Cancer With Bone Metastases
NCT05466812 ·Status: UNKNOWN ·Phase: PHASE4