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Restoring Molecular Circadian Rhythm

NCT04086589 · Status: SUSPENDED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2026-01-23

No results posted yet for this study

Summary

The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blood samples to "age" circadian rhythms in cultured cells. The investigators will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If the investigators identify specific genes that can restore molecular circadian rhythm in vitro, the investigators will explore these in animal models (Drosophila, mouse).

Conditions

  • Healthy Young
  • Healthy Elderly

Interventions

OTHER

Observational study without intervention

Observational study without intervention

Sponsors & Collaborators

Principal Investigators

  • Carsten Skarke, MD · University of Pennsylvania

Eligibility

Min Age
20 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-08-19
Primary Completion
2028-01-31
Completion
2028-11-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04086589 on ClinicalTrials.gov