MedTrace Logo

Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder

NCT04081519 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 53

Last updated 2021-08-04

No results posted yet for this study

Summary

This study aims to investigate the effects of individualized repetitive transcranial magnetic stimulation (rTMS) of parieto-hippocampal functional connectivity in patients with major depressive disorder (MDD). Specifically, patients will be randomized to one of three groups and will receive 15 days of rTMS over three weeks. Each day they will receive one active session of rTMS over the dorsolateral parietal cortex (DLPFC) and depending on group assignment another session either A) active rTMS over DLPFC, B) active rTMS over left and right lateral parietal cortex (LPC), or C) sham rTMS over DLPFC or LPC. Stimulation targets in the LPC will be individualized for each patient based on their resting-state functional connectivity between the hippocampus and LPC. Clinical, neuropsychological and fMRI data will be acquired before and after the treatment course.

Conditions

Interventions

DEVICE

active rTMS over DLPFC

15 sessions of active rTMS over DLPFC

DEVICE

Add-on active rTMS over DLPFC

15 additional sessions of active rTMS over DLPFC

DEVICE

Add-on active rTMS over LPC

15 additional sessions of active rTMS over LPC

DEVICE

Add-on sham rTMS

15 additional sessions of sham rTMS over DLPFC or LPC

Sponsors & Collaborators

  • Clemens Mielacher, University Hospital, Bonn

    collaborator UNKNOWN

  • University Hospital, Bonn

    lead OTHER

Principal Investigators

  • René Hurlemann, Prof. · University Hospital, Bonn

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-02
Primary Completion
2018-03-31
Completion
2018-06-22

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04081519 on ClinicalTrials.gov