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Personalized rTMS for Resistant Depression

NCT02863380 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 27

Last updated 2025-09-24

No results posted yet for this study

Summary

The investigators hypothesize that personalizing the rTMS targets using functional MRI will increase its efficacy. The most dysfunctional regions or the most dysfunctional network will be stimulated homogeneously. Individualized rTMS will be compared to traditional rTMS procedure and to trans-cranial direct current stimulation (tDCS) in a randomized cross-over trial.

In this pilot study the primary outcome measure will be the correction of the MRI anomalies. Symptoms reduction and the proportion of remitters will be secondary outcome measurements.

Conditions

  • Depressive Disorder
  • Treatment-Resistant

Interventions

PROCEDURE

Functional magnetic resonance imaging used to individualize rTMS protocol

Procedure consisting in personalizing the rTMS targets and stimulation pattern based on functional magnetic resonance imaging

DEVICE

Individualized rTMS (transcranial magnetic stimulation)

DEVICE

Classical rTMS (transcranial magnetic stimulation)

DEVICE

Classical tDCS (transcranial direct current stimulation)

Sponsors & Collaborators

  • University Hospital, Strasbourg, France

    lead OTHER

Principal Investigators

  • Jack FOUCHER, MD · Hôpitaux Universitaires de Strasbourg

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-05-04
Primary Completion
2021-01-21
Completion
2021-01-21

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02863380 on ClinicalTrials.gov