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Behavioral and Neural Representations of Subjective Effort Cost

NCT04041154 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 185

Last updated 2026-01-26

No results posted yet for this study

Summary

The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.

Conditions

Interventions

BEHAVIORAL

Cognitive Fatigue

Participants will perform a cognitively demanding task (spatial attention task), repeatedly, to induce cognitive fatigue.

BEHAVIORAL

Physical Fatigue

Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.

BEHAVIORAL

Rewarding Stimuli

Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

    lead OTHER

Principal Investigators

  • Vikram S. Chib, PhD · Kennedy Krieger Institute and Johns Hopkins School of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-01
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04041154 on ClinicalTrials.gov