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Effectiveness Study of Different Local Anesthetic Mixtures

NCT01243112 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2011-12-02

Study results available
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Summary

Purpose and Background The purpose of this research study is to investigate the benefits of mixing lidocaine and bupivacaine for numbing the skin. Lidocaine and bupivacaine are two commonly used medications to numb the skin for minor procedures. Lidocaine has a faster onset. Bupivacaine has a longer duration. They are often combined with epinephrine to increase the length of action. These medications are used to control pain at the time of the operation and to decrease discomfort immediately afterward. Participating in the study involves injection of local anesthetic containing lidocaine, bupivacaine, and lidocaine and bupivacain with epinephrine at 4 sites on the forearm. Your participation will potentially improve the administration of these medications in persons undergoing a variety of procedures. You will be one of approximately 25 healthy volunteer subjects in this research study.

Conditions

Interventions

DRUG

1% Lidocaine with Epinephrine (1:100,000)

0.2ml Intradermal injection once.

DRUG

0.25% Bupivacaine with Epinephrine (1:200,000)

0.2ml Intradermal injection once.

DRUG

0.5% Lidocaine, 0.125 Bupivacaine, and epi (1:150,000)

0.2ml Intradermal injection once.

DRUG

1% Lidocaine, 0.5% Bupivacaine, and epinephrine (1:150,000)

0.2ml Intradermal injection once.

Sponsors & Collaborators

  • Scott and White Hospital & Clinic

    lead OTHER

Principal Investigators

  • James B Collins, MD · Scott and White Healthcare

  • Raman C Mahabir, MD · Scott and White Healthcare

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-05-31
Primary Completion
2010-09-30
Completion
2010-09-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01243112 on ClinicalTrials.gov