Intralipid® 20% for Reversal of Local Anesthetics

Summary

In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits. Small amounts of local anesthetics will be injected into the volunteers' thighs during both visits. During one visit volunteers will receive Intralipid 20% and during the other visit they will receive a saline solution. The study team will measure how quickly normal sensation returns to the thighs when the volunteers get Intralipid 20% compared to saline.

Conditions

• Anesthesia, Local

Interventions

DRUG

Lidocaine 2%

3 mL of test solution to a skin area on the thigh, 2cm in diameter

DRUG

Lidocaine 1%

3 mL of test solution to a skin area on the thigh, 2cm in diameter

DRUG

Bupivacaine 0.25%

3 mL of test solution to a skin area on the thigh, 2cm in diameter

DRUG

Bupivacaine 0.5%

3 mL of test solution to a skin area on the thigh, 2cm in diameter

DRUG

Intralipid, 20% Intravenous

a 250ml bag administered intravenously

OTHER

Saline intravenously

a 250ml bag administered intravenously

OTHER

Saline

3 mL of test solution to a skin area on the thigh, 2cm in diameter

Sponsors & Collaborators

• Hospital for Special Surgery, New York

  lead OTHER

Principal Investigators

• Stavros Memtsoudis, MD/PhD · Hospital for Special Surgery, New York

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-07-26

Primary Completion

2026-10-31

Completion

2026-10-31

FDA Drug

Yes

Countries

• United States

Study Locations